HSP Research Foundation
Welcome to the HSP Research Foundation - created in 2005 to find an effective treatment for Hereditary Spastic Paraplegia (HSP) - an inherited, degenerative disease affecting mainly the legs, causing spasticity, muscle weakness and severely impairing walking.
The HSP Research Foundation is an incorporated, registered Australian charity that facilitates and funds research to find an effective treatment. The Foundation is also the community hub for HSPers in Australia, creating awareness and providing information, education and support.
Nerve axon regeneration and improved motor function
More answers, but also more questions
Correlated with disease duration and severity
Gene testing advances show complex picture
Other genes may be involved
Involved with both mitochondria and ER
Both pure and complicated forms of HSP
Research from US, China, Middle East and Greece
What is available for HSP in Australia
May help with chronic pain and spasticity
From a physio who has HSP
Available right around Australia
Information retrieval of human genes
Progress report from the research team
Toyota and Ritchies IGA add to the total
Both victims of rejection
A global voice for people with rare diseases
Mixed news over the last quarter
Spring 2015 edition
This space is for you to have your say. Email us
Important documents here
Summer 2015 edition to be published early December
If, when and how?
Anyone tried it for HSP?
has anyone received a payout?
Request for information and advice
Fundraising for HSP Research
The current phase of research - Testing & Selecting Therapeutic Drug Candidates for treating HSP - began in early 2013. Two promising candidate drugs are being investigated to determine their suitability for undertaking clinical trials. Currently, two validation studies are underway, one with HSP mice and the other with human HSP neurons derived from a different type of stem cell – induced pluripotent stem cells.
Success with any drug candidate in these separate investigations will make a solid case for taking the drug candidate into clinical trials to test its potential to be an effective treatment for HSP. Plans are underway to make application for, and seek approval for clinical trials in 2016.
With the funding for these drug validation studies now secure, the attention turns to funding the development of a database / registry of HSPers and the establishment costs in making clinical drug trials a reality. These costs are huge and there is no way we can meet them all, but it is essential that we play our part and do our best.
Thanks to your generous support, we well exceeded our 2014 fundraising target. An effective treatment for HSP is now within reach!