HSP Research Foundation

Welcome to the HSP Research Foundation - created in 2005 to find a cure for Hereditary Spastic Paraplegia - an inherited, degenerative disease affecting mainly the legs, causing muscle weakness, spasticity and severely impairing walking.

The HSP Research Foundation is an incorporated, registered Australian charity that facilitates and funds research to find a cure. The Foundation is also the community hub for HSPers in Australia, creating awareness and providing support and education.

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Discovery doubles number of HSP causes

Genes never before linked with human disease found

Inheritance patterns in HSP easy to misinterpret

Implications for choice of genetic tests and screens

Why is most HSP adult-onset?

Current theories fall short

Gene protects against neurodegenerative diseases

May lead to a number of cures

Induced pluripotent HSP stem cell study

Human model for drug screening

REEP1 affects Lipid Droplet biology

May be critical for nerve cell function

One gene mutation, three diseases

ALS2 mutations cause ALS, PLS or HSP

HSP and Parkinson’s

Impaired dopamine transmission in common

Does footwear affect balance?

Helping prevent falls

Custom-built tricycle

Bathurst pair team up

Implantable foot drop stimulator

Results suggest potential therapeutic option

‘Towards a Cure for HSP’ research program update1

Promising progress… and a long way to go

Rare Disease Day, 28 February 2014

Day of global support for rare diseases

National Disability Insurance Scheme update

Full Government commitment is essential

Participate more in the HSP community

Submit a Community Member profile

Newsletters of other HSP groups

US Synapse & UK Newslink

This space is for you to have your say. Email us

Disability Pension and HSP2

Request for information and advice

Autumn edition published 27 February 2014

Winter 2014 edition in early June

Swollen feet and legs4

related to HSP?

MS drug for HSP?2

HSPer trys Fampradine (Fampyra)

HSP and neuropathy2

Ideas for treating the pain?

Fundraising for HSP Research

The current phase of research begun in 2013 in the Towards a Cure for HSP research program is titled Testing & Selecting Therapeutic Drug Candidates for treating HSP.

Two promising candidate drugs are being investigated to determine their suitability for undertaking clinical trials. The current drug investigations are being carried out with nasal HSP stem cells. Two new investigations are in the advanced planning stage, one with HSP mice and the other with human HSP neurons derived from a different type of stem cell.

Success with a drug candidate in these separate investigations will make a very strong case for taking the drug candidate into human clinical trials to test its potential to cure HSP.

Our fundraising performance in calendar 2013 was only modest. We encourage everyone in the HSP community to be determined to find a way to fund the current and planned research in 2014, as nobody wants the research work to slow down in the quest to find suitable candidates for taking to clinical trials and the possibility of a cure for HSP. Please give generously to ensure continuity of research towards a cure for HSP.

2014

2013

$75,000
$67,500
$60,000
$52,500
$45,000
$37,500
$30,000
$22,500
$15,000
$7,500
$0
$75,000
$67,500
$60,000
$52,500
$45,000
$37,500
$30,000
$22,500
$15,000
$7,500
$0